Search results for " adherent cells"
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
A unique characteristic of adherent cells is their dependence on an anchorage surface on which to attach to exert their normal metabolic activity and proliferate. While cell attachment may prove advan…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
For adherent cells in FBRs, inoculum preparation will include growing cells initially in flatware and then in multi-tray dish(es). Cells are enzymatically detached to seed the FBR. Particular care mus…
Article
Direct adaptation of adherent cell lines in classical media
Discover the options for direct adaptation of common adherent cell lines.
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Single-Use Technologies Prove Effective for Viral Vector Process Development
“Traditional laboratory-scale systems, such as roller bottles or cell factories designed for use with adherent cells, are generally used for small-scale production of viral vectors, while fixed-bed cu…
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Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Mapping a Route for Cell and Gene Therapy Process Development
“The ability to transfer production systems for adherent cells to bioreactors aids in the scale up of these processes. Bioreactors can be used as closed systems and provide the opportunity to scale up…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities.
By Feliza Mirasol
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Tools for Continuous Bioprocessing Development
Could perfusion microbioreactors bring more agility to biomanufacturing?
By Rajeev J. Ram
In semiconductor manufacturing, for example, a thorough understanding of process variation allows co…
Article
Improving Upstream Predictability
Today, notes Castan, most processes for the production of viral vectors are based on adherent cells, but new expression systems with suspension cells are being developed. These systems will allow exis…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The aim of this white paper is to demonstrate how Cytiva single-use products can be applied in the field of vaccine manufacturing. The white paper includes a brief discussion around modern vacci…